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■Appendices

Figure 6: Search flow diagram for study selection.

• Models of immunity to malaria (deterministic and agent/individual-based), which

address some dynamic topics relating to the disease infection, such as superinfection

parasite strains and duration of infection (top).

The density visualization (Figure 8) also gives an overview of the important areas in the

map, with immunity being the center of concentration from where all the other terms are

linked directly or indirectly and thus, the thickest.

The visualization of the relatedness of included studies in terms of citations is given

in Figure 9. The label may not be displayed for some of the documents in order to avoid

overlapping labels. The papers are arranged in three clusters:

• The ABMs of acquired immunity to malaria (extreme right corner)

• The mathematical models of acquired immunity to malaria (left-hand side)

• Other studies that are not necessarily model-based but support and explain the un-

derlying mechanisms of acquired immunity to malaria (middle).

The density visualization in Figure 10 reveals that not much studies have considered

modeling with the agent-based approach.